The regulation of feed intake consists of several overlapping neural and endocrine pathways involved in negative as well as positive feedback mechanisms several centres in the brain are responsible for the capture and integration of internal and external signals. Except in a few cases kaushik et al in press paspatis et al 2003 in most of the studies on the effect of feed intake on growth of sea bass fish were fed a fixed amount of food or in some cases hand fed to satiation so that the capacity of european sea bass to regulate their feed intake in relation to the digestible energy de content of the diet remains little explored. Regulation of food intake metabolic expenditure cannot exceed food intake for very long if an animal is to survive one way to equalize the two processes is to decrease metabolism to a level sustainable by maximum intake which may be limited by the ability to extract food from a meagre habitat. Physiological regulation of feed intake nutrients and their metabolites regulate short and long term feed intake through direct or indirect endocrine secretions that interact with local and central neural processes